tailieunhanh - báo cáo hóa học: " On the potential role of glutamate transport in mental fatigue"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: On the potential role of glutamate transport in mental fatigue | Journal of Neuroinflammation BioMed Central Hypothesis Open Access On the potential role of glutamate transport in mental fatigue Lars Ronnback and Elisabeth Hansson Address Institute of Clinical Neuroscience Goteborg University Goteborg Sweden Email Lars Ronnback - Elisabeth Hansson - Corresponding author Published 04 November 2004 Received 30 August 2004 Accepted 04 November 2004 Journal of Neuroinflammation 2004 1 22 doi 1742-2094-1-22 This article is available from http content 1 1 22 2004 Ronnback and Hansson licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Mental fatigue with decreased concentration capacity is common in neuroinflammatory and neurodegenerative diseases often appearing prior to other major mental or physical neurological symptoms. Mental fatigue also makes rehabilitation more difficult after a stroke brain trauma meningitis or encephalitis. As increased levels of proinflammatory cytokines are reported in these disorders we wanted to explore whether or not proinflammatory cytokines could induce mental fatigue and if so by what mechanisms. It is well known that proinflammatory cytokines are increased in major depression sickness behavior and sleep deprivation which are all disorders associated with mental fatigue. Furthermore an influence by specific proinflammatory cytokines such as interleukin IL -1 on learning and memory capacities has been observed in several experimental systems. As glutamate signaling is crucial for information intake and processing within the brain and due to the pivotal role for glutamate in brain metabolism dynamic alterations in glutamate transmission could be of .

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