tailieunhanh - báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis | Journal of Neuroinflammation BioMed Central Research Open Access Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis Yuemang Yao1 Cinzia Chinnici1 Hanguan Tang1 John Q Trojanowski2 3 Virginia MY Lee2 3 and Domenico Praticò 1 Address 1Center for Experimental Therapeutics and Department of Pharmacology University of Pennsylvania School of Medicine Philadelphia PA 19104 USA 2Center for Neurodegenerative Disease Research University of Pennsylvania School of Medicine Philadelphia PA 19104 USA and 3Institute on Aging University of Pennsylvania School of Medicine Philadelphia PA 19104 USA Email Yuemang Yao - yuemang@ Cinzia Chinnici - cinzia@ Hanguan Tang - hanguan@ John Q Trojanowski - trojanowsi@ Virginia MY Lee - lee@ Domenico Praticò - domenico@ Corresponding author Published 22 October 2004 Received 22 September 2004 Accepted 22 October 2004 Journal of Neuroinflammation 2004 1 21 doi 1742-2094-1-21 This article is available from http content 1 1 21 2004 Yao et al licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background An increasing body of evidence implicates both brain inflammation and oxidative stress in the pathogenesis of Alzheimer s disease AD . The relevance of their interaction in vivo however is unknown. Previously we have shown that separate pharmacological targeting of these two components results in amelioration of the amyloidogenic phenotype of a transgenic mouse model of AD-like brain amyloidosis Tg2576 . Methods In the present study we investigated the therapeutic effects of a combination of an antiinflammatory agent indomethacin