tailieunhanh - báo cáo hóa học: " Using animal models to determine the significance of complement activation in Alzheimer's disease"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Using animal models to determine the significance of complement activation in Alzheimer's disease | Journal of Neuroinflammation BioMed Central Review Open Access Using animal models to determine the significance of complement activation in Alzheimer s disease David A Loeffler Address Department of Neurology William Beaumont Hospital Research Institute Royal Oak MI 48073 USA Email David A Loeffler - DLoeffler@ Corresponding author Published 12 October 2004 Received 05 August 2004 Journal ofNeuroinflammation 2004 1 18 doi l742-2094-l-l8 Accepted 12 October 2004 This article is available from http content l l l8 2004 Loeffler licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Complement inflammation is a major inflammatory mechanism whose function is to promote the removal of microorganisms and the processing of immune complexes. Numerous studies have provided evidence for an increase in this process in areas of pathology in the Alzheimer s disease AD brain. Because complement activation proteins have been demonstrated in vitro to exert both neuroprotective and neurotoxic effects the significance of this process in the development and progression of AD is unclear. Studies in animal models of AD in which brain complement activation can be experimentally altered should be of value for clarifying this issue. However surprisingly little is known about complement activation in the transgenic animal models that are popular for studying this disorder. An optimal animal model for studying the significance of complement activation on Alzheimer s - related neuropathology should have complete complement activation associated with senile plaques neurofibrillary tangles if present and dystrophic neurites. Other desirable features include both classical and alternative pathway .