tailieunhanh - A–Z of Haematology - part 5

Down hội chứng một hội chứng bẩm sinh của chậm phát triển tâm thần với tính năng đặc trưng dysmorphic như một hệ quả của trisomy 21 (hoặc thảo làm ba bổn của một khu vực quan trọng cụ thể của nhiễm sắc thể 21), ở trẻ sơ sinh có thể gây ra polycythaemia và myelopoiesis bất thường thoán | 90 double helix double helix the tertiary structure of DNA double minute chromosome dm an abnormal chromosome with two chromatids and no centromere . an acentric fragment of a chromosome down regulation a reduction in the number of receptors of a specific type on a cell surface as the result of reduced expression of the relevant gene Down s syndrome a congenital syndrome of mental retardation with characteristic dysmorphic features as a consequence of trisomy 21 or of triplication of a specific critical region of chromosome 21 in neonates may cause polycythaemia and transient abnormal myelopoiesis in infants and older children is associated with an increased incidence of acute lymphoblastic leukaemia and acute myeloid leukaemia particularly acute megakaryoblastic leukaemia doxorubicin an anthracycline antibiotic used in the treatment of lymphoma and various carcinomas and sarcomas 2 3-DPG 2 3-diphosphoglycerate drumstick a nuclear appendage in females that contains the inactive X chromosome dry tap jargon for an attempted bone marrow aspiration that yields nothing dsDNA double-stranded DNA Du see RHD Duffy a system of blood group antigens CD234 Duffy antigens are receptors for Plasmodium vivax and for several classes of pro-inflammatory cytokines see also FY Duncan s syndrome a sex-linked recessive condition in which there is abnormal susceptibility to Epstein-Barr virus infection resulting from mutation of the SAP gene at Xq25 now generally known as the X-linked lymphoproliferative syndrome duodenum the most proximal part of the small intestine that connects the stomach to the jejunum the site of maximal iron absorption dup a cytogenetic abbreviation indicating a duplication duplication duplication of a gene or DNA sequence encompassing several genes or duplication of a segment of a chromosome the latter detectable by conventional cytogenetic analysis and designated dup Dutcher body an intranuclear inclusion in a plasma cell caused by invagination of .

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