tailieunhanh - A–Z of Haematology - part 4

chủ yếu là một điều tiêu cực của kích hoạt tế bào T-, mis-cảm giác đột biến ở codon 17 đã được báo cáo là liên quan với endocrinopathies tự miễn, một protein CD152immunoglobulin nhiệt hạch đã được sử dụng thử nghiệm trong điều trị bệnh vẩy nến CD153 một cytokine, phối tử CD30 CD30L, cho thấy tương đồng với yếu tố hoại tử khối u, thể hiện trên bạch cầu trung tính | CD158b 65 mainly a negative regulator of T-cell activation mis-sense mutations in codon 17 have been reported to be associated with autoimmune endocrinopathies a CD152-immunoglobulin fusion protein has been used experimentally in the treatment of psoriasis CD153 a cytokine CD30 ligand or CD30L shows homology with tumour necrosis factor expressed on neutrophils activated T cells monocytes and macrophages CD153 CD30 ligand is expressed together with CD30 on the neoplastic cells of cutaneous anaplastic large cell lymphoma with overexpression probably contributing to spontaneous regression CD154 a protein CD40 ligand or CD40L expressed on activated CD4 lymphocytes expression being essential for normal signalling to B cells particularly for isotype switching mutations in the CD154 gene are responsible for the X-linked immunodeficiency syndrome the hyperIgM syndrome expressed on monocytes macrophages eosinophils basophils NK cells platelets dendritic cells epithelial cells endothelial cells and fibroblasts on platelet activation CD154 moves to the surface membrane and has the potential to interact with CD40 on endothelial cells leading to an inflammatory reaction which is limited by binding of CD154 to co-expressed platelet CD40 CD 154 stimulates myelopoiesis particularly megakaryocytopoiesis by up-regulating flt3-ligand and throm-bopoietin CD154 expression on CD4 lymphocytes is increased in HIV infection and may contribute to hyperimmuno-globulinaemia CD154 in the supernatant may cause febrile reactions following platelet transfusion monoclonal antibodies to CD154 have been used in the therapy of autoimmune thrombocytopenic purpura and to facilitate allogenic engraftment CD 154 is co-expressed with CD40 on some non-Hodgkin s cells so that an autocrine loop may occur it is coexpressed with CD40 on cells of some cases of chronic lymphocytic leukaemia soluble CD154 is increased in chronic lymphocytic leukaemia and could promote cell survival strongly expressed on hairy .

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