tailieunhanh - Atlas of Clinical Hematology - part 5

Pappenheim cho thấy vết hemosiderin lắng đọng trong một tế bào plasma (bên trái). Ở bên phải là màu xương tủy sắt từ cùng một bệnh nhân. Lưu ý sự lắng đọng sắt dạng hạt thô trong tế bào chất của một tế bào huyết tương trong RARS. Nucleus là ở phía dưới bên phải. | 168 Chapter IV Blood and Bone Marrow Fig. 61 a Fig. 61 b 169 IV 5 Bone Marrow Fig. 62 a-d a Massive iron deposition including coarse clumps in a bone marrow fragment in MDS partly transfusion-related b Pappenheim stain shows hemosiderin deposition in a plasma cell left . At right is iron-stained bone marrow from the same patient. Note the coarse granular iron deposition in the cytoplasm of a plasma cell in RARS. Nucleus is at lower right. c-f The 5q-minus syndrome c Two megakaryocytes with round nuclei and different stages of cytoplasmic maturity - a typical finding in this syndrome d Three typical megakaryocytes with round nuclei and relatively mature cytoplasm 170 Chapter IV Blood and Bone Marrow Fig. 62e-f e Large megakaryocyte with a nonsegmented nucleus. The cytoplasm is still partly basophilic. Below the megakaryocyte is an erythroblast in mitosis and a myeloblast f Erythropoiesis showing subtle megaloblastic features in 5q-minus syndrome Fig. 63. Schematic diagram and partial karyotype of the deletion on the long arm of chromosome 5 del 5 q13q31 the so-called 5q-minus syndrome which in addition is found in the setting of complex aberrant clones in .