tailieunhanh - ANEMIAS AND OTHER RED CELL DISORDERS - PART 9

Sàng lọc rộng rãi của các cá nhân từ các quần thể β-thalassemia đặc điểm phổ biến đã cho phép chẩn đoán trước khi sinh thai nhi bị ảnh hưởng. Trong các cộng đồng người Mỹ Hy Lạp, Mỹ và Ý, số lượng của trẻ sơ sinh bị ảnh hưởng đã giảm mạnh. Số lượng trẻ em với bệnh thiếu máu ở Hoa Kỳ đang tăng lên | 300 HEMOGLOBIN DISORDERS SECTION V of these A former childhood disorder is increasingly a disease of adults. Widespread screening of individuals from populations where ft-thalassemia trait is prevalent has enabled prenatal diagnosis of affected fetuses. In Greek American and Italian American communities the number of affected infants has sharply decreased. The number of children with thalassemia in the United States is rising however as a result of the increase in the number of Americans of Southeast Asian ancestry. These more recent arrivals to the country have not yet achieved the cohesive approach to thalassemia that proved so successful in other American communities. Until this goal is reached thalassemia will remain an important issue in American medicine Tables 14-3 and 14-4 . References 1 Cooley TB Witwer ER Lee P. 1927. Anemia in children with splenomegaly and peculiar changes in bones Report of cases. Am J Dis Child 34 347-355. 2 Olivieri NF. 1999. The beta-thalassemias. N Engl J Med 341 99-109. 3 Wasi P Winichagoon P Baramee T Fucharoean S. 1982. Globin chain synthesis in heterozygous and homozygous hemoglobin E. Hemoglobin 6 75-78. 4 Fairbanks VF Gilchrist GS Brimhall B Jereb JA Goldston EC. 1979. Hemoglobin E trait revisited A cause of microcytosis and erythrocytosis. Blood 53 109-115. 5 Fairbanks VF Oliveros R Brandabur JH Willis RR Fiester RF. 1980. Homozygous hemoglobin E mimics b-thalassemia minor without anemia or hemolysis Hematologic functional and biosynthetic studies of first North American cases. Am J Hematol 8 109121. 6 Rees DC Styles L Vichinsky EP Clegg JB Weatherall DJ. 1998. The hemoglobin E syndromes. Ann N Y Acad Sci 850 334-343. 7 Fucharoen S Ketvichit P Pootrakul P Siritanaratkul N Piankijagum A Wasi P 2000. Clinical manifestation of beta thalassemia hemoglobin E disease. J Pediatr Hematol Oncol 22 552-557. 8 Chui DH Fucharoen S Chan V. 2003. Hemoglobin H disease Not necessarily a benign disorder. Blood 101 791-800. 9 Chen