tailieunhanh - báo cáo hóa học: " Low plasma progranulin levels in children with autism"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Low plasma progranulin levels in children with autism | AL-Ayadhi and Mostafa Journal of Neuroinflammation 2011 8 111 http content 8 1 111 JJOURNAL1 OF. NEUROINFLAMMATION RESEARCH Open Access Low plasma progranulin levels in children with autism Laila Y AL-Ayadhi1 and Gehan A Mostafa1 2 Abstract Background Autoimmunity to brain may play a pathogenic role in autism. In autoimmune disorders the formation of antigen-antibody complexes triggers an inflammatory response by inducing the infiltration of neutrophils. Local administration of recombinant progranulin which is an anti-inflammatory neurotrophic factor potently inhibit neutrophilic inflammation in vivo demonstrating that progranulin represents a crucial inflammation-suppressing mediator. We are the first to measure plasma progranulin levels in autism. Methods Plasma levels of progranulin were measured by ELISA in 40 autistic patients aged between 3 and 12 years and 40 healthy-matched children. Results Autistic children had significantly lower plasma progranulin levels P . Reduced plasma progranulin levels were found in 65 26 40 of autistic children. On the other hand there was a non significant difference between plasma progranulin levels of children with mild to moderate autism and patients with severe autism P . Conclusions Plasma progranulin levels were reduced in a subgroup of patients with autism. Progranulin insufficiency in some patients with autism may result in many years of reduced neutrotrophic support together with cumulative damage in association with dysregulated inflammation that may have a role in autism. However these data should be treated with caution until further investigations are performed with a larger subject population to determine whether the decrease of plasma progranulin levels is a mere consequence of autism or has a pathogenic role in the disease. The role of progranulin therapy should also be studied in autism. Keywords Autism autoimmunity neutrophils progranulin. Background A possible role of .