tailieunhanh - báo cáo hóa học: " Wallerian degeneration: the innate-immune response to traumatic nerve injury"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Wallerian degeneration: the innate-immune response to traumatic nerve injury | JOURNAL OF NEUROINFLAMMATION Wallerian degeneration the innate-immune response to traumatic nerve injury Rotshenker Rotshenker Journal of Neuroinflammation 2011 8 109 http content 8 1 109 30 August 2011 BioMed Central Rotshenker Journal of Neuroinflammation 2011 8 109 http content 8 1 109 JIOURNAL1 OF. NEUROINFLAMMATION REVIEW Open Access Wallerian degeneration the innate-immune response to traumatic nerve injury Shlomo Rotshenker Abstract Traumatic injury to peripheral nerves results in the loss of neural functions. Recovery by regeneration depends on the cellular and molecular events of Wallerian degeneration that injury induces distal to the lesion site the domain through which severed axons regenerate back to their target tissues. Innate-immunity is central to Wallerian degeneration since innate-immune cells functions and molecules that are produced by immune and non-immune cells are involved. The innate-immune response helps to turn the peripheral nerve tissue into an environment that supports regeneration by removing inhibitory myelin and by upregulating neurotrophic properties. The characteristics of an efficient innate-immune response are rapid onset and conclusion and the orchestrated interplay between Schwann cells fibroblasts macrophages endothelial cells and molecules they produce. Wallerian degeneration serves as a prelude for successful repair when these requirements are met. In contrast functional recovery is poor when injury fails to produce the efficient innate-immune response of Wallerian degeneration. Keywords Wallerian degeneration macrophage phagocytosis cytokine myelin Introduction Traumatic injury to nerves in the PNS peripheral nervous system results in the loss of neural functions. Rep air is achieved through regeneration of severed axons and reinnervation of target tissues. Successful functional recovery depends on the ensemble of cellular and molecular events that develop distal to .