tailieunhanh - Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica

In the modified gambling task, subjects selected cards from one of two decks to earn cash. The cards were pre-organized so that one deck (A) had an overall loss of $ every ten cards and the other deck (B) had an overall gain of $ every ten cards. All the cards in deck A gave a $ on every turn but were occasionally accompanied with losses, $ for example (for a net loss of $). The other deck B gave a smaller gain for each card, +$ but had smaller occasional losses. Subjects did not know the composition. | Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica Jintanaporn Wattanathorna Lugkana Matorb Supaporn Muchimapuraa Terdthai Tongun a Orapin Pasuriwonga Nawanant Piyawatkulc Kwanchanok Yimtaed Bungorn Sripanidkulchaie Jintana Singkhoraardc a Department of Physiology Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand b Department of Physiology and Biomedical Science Program Graduate School Khon Kaen University Khon Kaen 40002 Thailand c Department of Psychiatry Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand d Department of Otolaryngology Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand e Center for Research and Development of Herbal Health Product Faculty of Pharmaceutical Sciences Khon Kaen University Khon Kaen 40002 Thailand Received 21 February 2007 received in revised form 21 November 2007 accepted 28 November 2007 Available online 4 December 2007 Abstract Aims of this study Centella asiatica has a reputation to restore decline cognitive function in traditional medicine and in animal model. However little evidence regarding the efficacy of Centella asiatica from systematized trials is available. Therefore the present randomized placebo-controlled double-blind study investigated the effect of Centella asiatica on cognitive function of healthy elderly volunteer. Materials and methods Twenty-eight healthy elderly participants received the plant extract at various doses ranging 250 500 and 750 mg once daily for 2 months. Cognitive performance was assessed using the computerized test battery and event-related potential whereas mood was assessed using Bond-Lader visual analogue scales prior to the trial and after single 1 and 2 months after treatment. Results The results showed that the high dose of the plant extract enhanced working memory and increased N100 component amplitude of event-related potential. Improvements of self-rated mood were also