tailieunhanh - Memory performance in healthy elderly without Alzheimer’s disease: effects of time and apolipoprotein-E

The Netherlands may be an extreme case in this respect, but strong incentive effects have also been found for other countries. With respect to Disability application behaviour in other countries like the United States, Germany and Sweden, it has been argued that labour supply (and labour demand) considerations may have taken place in the decision to apply for benefits. To quote Bound and Burkhauser (1999): “the prevalence of disability transfer recipients per worker has increased at all working ages over the last quarter of the century. | Neurobiology of Aging 22 2001 683-689 NEUROBIOLOGY OF AGING locate neuaging Memory performance in healthy elderly without Alzheimer s disease effects of time and apolipoprotein-E Richard Mayeux MD MSca b d eX Scott A. Small MDa b e Ming-Xin Tang PhDa g Benjamin Tycko MD PhDc e Yaakov Stern PhDa b d e aGertrude H. Sergievsky Center School of Public Health Columbia University College of Physicians and Surgeons New York New York USA Department of Neurology School of Public Health Columbia University College of Physicians and Surgeons New York New York USA cDepartment of Pathology School of Public Health Columbia University College of Physicians and Surgeons New York New York USA dDepartment of Psychiatry School of Public Health Columbia University College of Physicians and Surgeons New York New York USA eTaub Institute for Research in Alzheimer s Disease and the Aging Brain School of Public Health Columbia University College of Physicians and Surgeons New York New York USA fDivision of Epidemiology School of Public Health Columbia University College of Physicians and Surgeons New York New York USA gDivision of Biostatistics School of Public Health Columbia University College of Physicians and Surgeons New York New York USA Received 4 December 2000 received in revised form 4 December 2000 accepted 30 January 2001 Abstract Transgenic mice expressing human APOE- 4 develop an age-dependent decline in memory without pathological features of Alzheimer s disease AD . This implicates APOE in the maintenance of memory during normal senescence but parallel human studies are limited because longitudinal investigations of memory usually do not exclude patients with AD or questionable AD QD . The current stady examined the effect of APOE on cognitive function over time in elderly without dementia. We hypothesized that compared to other APOE alleles memory decline even in healthy elderly would be greater among those with an APOE- 4. The results of .