tailieunhanh - báo cáo hóa học: " Methyl salicylate 2-O-b-D-lactoside, a novel salicylic acid analogue, acts as an antiinflammatory agent on microglia and astrocytes"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Methyl salicylate 2-O-b-D-lactoside, a novel salicylic acid analogue, acts as an antiinflammatory agent on microglia and astrocytes | Lan et al. Journal of Neuroinflammation 2011 8 98 http content 8 1 98 JJOURNAL1 OF. NEUROINFLAMMATION SHORT REPORT Open Access Methyl salicylate 2-O-b-D-lactoside a novel salicylic acid analogue acts as an antiinflammatory agent on microglia and astrocytes Xi Lan Rui Liu Lan Sun Tiantai Zhang and Guanhua Du Abstract Background Neuroinflammation has been known to play a critical role in the pathogenesis of Alzheimer s disease AD . Activation of microglia and astrocytes is a characteristic of brain inflammation. Epidemiological studies have shown that long-term use of non-steroidal anti-inflammatory drugs NSAIDs delays the onset of AD and suppresses its progression. Methyl salicylate-2-O-j8-D-lactoside DL0309 is a new molecule chemically related to salicylic acid. The present study aimed to evaluate the anti-inflammatory effects of DL0309. Findings Our studies show that DL0309 significantly inhibits lipopolysaccharide LPS -induced release of the pro-inflammatory cytokines IL-6 IL-1Ị3 and TNF-a and the expression of the inflammation-related proteins iNOS COX-1 and COX-2 by microglia and astrocytes. At a concentration of 10 pM DL0309 prominently inhibited LPS-induced activation of NF-kB in glial cells by blocking phosphorylation of IKK and p65 and by blocking IkB degradation. Conclusions We demonstrate here for the first time that DL0309 exerts anti-inflammatory effects in glial cells by suppressing different pro-inflammatory cytokines and iNOS NO. Furthermore it also regulates the NF-kB signaling pathway by blocking IKK and p65 activation and IkB degradation. DL0309 also acts as a non-selective COX inhibitor in glial cells. These studies suggest that DL0309 may be effective in the treatment of neuroinflammatory disorders including AD. Findings Alzheimer s disease AD is a progressive neurodegenera-tive disorder of the elderly characterized by global deficits in cognition ranging from loss of memory to impaired judgment. It has been .