tailieunhanh - báo cáo hóa học: " ELISA measurement of specific non-antigenbound antibodies to Ab1-42 monomer and soluble oligomers in sera from Alzheimer’s disease, mild cognitively impaired, and noncognitively impaired subjects"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: ELISA measurement of specific non-antigenbound antibodies to Ab1-42 monomer and soluble oligomers in sera from Alzheimer’s disease, mild cognitively impaired, and noncognitively impaired subjects | Klaver et al. Journal of Neuroinflammation 2011 8 93 http content 8 1 93 JJOURNAL1 OF. NEUROINFLAMMATION RESEARCH Open Access ELISA measurement of specific non-antigenbound antibodies to Ab 1-42 monomer and soluble oligomers in sera from Alzheimer s disease mild cognitively impaired and noncognitively impaired subjects AnHrasỉ lAlsỉx ar 1 L I n D nfíAi 2 I nn a i i Crnifta1 r mx iA A Rannaff3 4 In An K l Rinlzo5 I non rìsỉnni6 Aiiuied C Kldver ividiy r Coney Lyn Ide M Smim Ddvid A Beiieii Joni M riike Lodi Ddig did David A Loeffler1 Abstract Background THe literature contdins coiflictiig results regdrding the stdtus of serum driti-Ap ditibody concentrdtions ii Alzheimer s disedse AD . Reduced levels of these ditibodies Hdve beei suggested to coitribute to the developmeit of this disorder. The coiflictiig results mdy be due to polyvdleit ditibodies ditibody mdskiig due to Ap biidiig methodologicdl differeices did or smdll sdmple sizes. The objectives of this pilot study were to compdre serum diti-Ap ditibody coiceitrdtiois betweei AD mild cogiitive impdirmeit MCI did elderly ioicogiitively impdired NCI subjects while dddressiig these issues did to perform power didlyses to determiie dppropridte group sizes for future studies employiig this dpprodch. Methods Serum ditibodies to Api-42 moiomer did soluble oligomers ii AD MCI did NCI subjects 10 group were medsured by ELISA subtrdctiig polyvdleit ditibody biidiig did dissocidtiig ditibody-ditigei complexes. Differeices ii medi ditibody levels were dssessed for sigiificdice with repedted medsures ANOVA usiig restricted mdximum likelihood estimdtioi usiig Tukey-Krdmer tests did coifideice iitervdls for multiple compdrisois. Spedrmdi s rdik correldtioi wds used to determiie dssocidtiois betweei diti-moiomer did diti-oligomer ditibody coiceitrdtiois. Estimdted sdmple sizes required to detect effects of vdrious sizes were cdlculdted. Results There were io sigiificdit differeices betweei groups for