tailieunhanh - báo cáo hóa học: " Microglia activation in sepsis: a case-control study"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Microglia activation in sepsis: a case-control study | Journal of Neuroinflammation BioMed Central Open Access Microglia activation in sepsis a case-control study Afina W Lemstra 1 Jacqueline CM Groen in t Woud1 Jeroen JM Hoozemans2 Elise S van Haastert2 Annemiek JM Rozemuller2 Piet Eikelenboom1 and Willem A van Gool1 Address Department of Neurology Academic Medical Centre PO Box 22660 1100DDAmsterdam The Netherlands and - Department of Neuropathology Academic Medical Centre PO Box 22660 1100DDAmsterdam The Netherlands Email Afina W Lemstra - Jacqueline CM Groen in t Woud - jgroenintwoud@ Jeroen JM Hoozemans - Elise S van Haastert - Annemiek JM Rozemuller - Piet Eikelenboom - piete@ Willem A van Gool - Corresponding author Published 15 January 2007 Received 18 October 2006 Journal of Neuroinflammation 2007 4 4 doi l742-2094-4-4 Accepted I5 January 2007 This article is available from http content 4 1 4 2007 Lemstra et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background infection induces an acute phase response that is accompanied by non-specific symptoms collectively named sickness behavior. Recent observations suggest that microglial cells play a role in mediating behavioral changes in systemic infections. In animal models for sepsis it has been shown that after inducing lipopolysaccharide LPS microglia in the brain were activated. The aim of this study was to investigate whether activation of microglia can be detected in patients who died of sepsis. Methods in a case-control study brain tissue of 13 patients .