tailieunhanh - báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease | Journal of Neuroinflammation BioMed Central Review Open Access The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer s disease Brandy L Wilkinson and Gary E Landreth Address Alzheimer Laboratory Department of Neuroscience Case Western Reserve University Cleveland OH 44106 USA Email Brandy L Wilkinson - blw9@ Gary E Landreth - gel2@ Corresponding author Published 09 November 2006 Received 25 September 2006 Accepted 09 November 2006 Journal of Neuroinflammation 2006 3 30 doi 1742-2094-3-30 This article is available from http content 3 1 30 2006 Wilkinson and Landreth licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Alzheimer s disease is the most common cause of dementia in the elderly and manifests as progressive cognitive decline and profound neuronal loss. The principal neuropathological hallmarks of Alzheimer s disease are the senile plaques and the neurofibrillary tangles. The senile plaques are surrounded by activated microglia which are largely responsible for the proinflammatory environment within the diseased brain. Microglia are the resident innate immune cells in the brain. In response to contact with fibrillar beta-amyloid microglia secrete a diverse array of proinflammatory molecules. Evidence suggests that oxidative stress emanating from activated microglia contribute to the neuronal loss characteristic of this disease. The source of fibrillar betaamyloid induced reactive oxygen species is primarily the microglial nicotinamide adenine dinucleotide phosphate NADPH oxidase. The NADPH oxidase is a multicomponent enzyme complex that upon activation produces the highly reactive free radical superoxide. The cascade of .