tailieunhanh - báo cáo hóa học: " Secretory PLA2-IIA: a new inflammatory factor for Alzheimer's disease"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Secretory PLA2-IIA: a new inflammatory factor for Alzheimer's disease | Journal of Neuroinflammation BioMed Central Open Access Secretory PLA2-IIA a new inflammatory factor for Alzheimer s disease Guna SD Moses11 Michael D Jensen12 Lih-Fen Lue1 Douglas G Walker1 Albert Y Sun3 Agnes Simonyi2 and Grace Y Sun 2 Address laboratory of Neuroinflammation Sun Health Research Institute Sun City AZ 85372 USA 2Biochemistry Department University of Missouri-Columbia Columbia MO 65211 USA and 3Department of Medical Pharmacology and Physiology University of Missouri-Columbia Columbia MO 65211 USA Email Guna SD Moses - Michael D Jensen - mdjensen@ Lih-Fen Lue - Douglas G Walker - Albert Y Sun - suna@ Agnes Simonyi - simonyia@ Grace Y Sun - sung@ Corresponding author fEqual contributors Published 07 October 2006 Received 27 April 2006 Journal of Neuroinflammation 2006 3 28 doi 1742-2094-3-28 Accepted 07 October 2006 This article is available from http content 3 1 28 2006 Moses et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Secretory phospholipase A2-IIA sPLA2-IIA is an inflammatory protein known to play a role in the pathogenesis of many inflammatory diseases. Although this enzyme has also been implicated in the pathogenesis of neurodegenerative diseases there has not been a direct demonstration of its expression in diseased human brain. In this study we show that sPLA2-IIA mRNA is up-regulated in Alzheimer s disease AD brains as compared to non-demented elderly brains ND . We also report a higher percentage of sPLA2-IIA-immunoreactive astrocytes present in AD .