tailieunhanh - báo cáo hóa học: " Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD | Journal of Neuroinflammation BioMed Central Research Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD Carol A Colton 1 Ryan T Mott1 Hayley Sharpe2 Qing Xu1 William E Van Nostrand3 and Michael P Vitek1 Open Access Address 1Duke University Medical Center Division of Neurology Durham NC 27710 USA 2University of Bath Department of Biology and Biochemistry Clavertone Down Bath BA2 7AY UK and 3Department of Medicine Stony Brook University Stony Book NY 11794 USA Email Carol A Colton - glia01@ Ryan T Mott - mott0003@ Hayley Sharpe - bs2hjs@ Qing Xu - qxu001@ William E Van Nostrand - wvannst@ Michael P Vitek - vitek001@ Corresponding author Published 27 September 2006 Received 25 July 2006 _. AAAZ J .IA I loz i-TXA AAO - - -r Accepted 27 September 2006 Journal of Neuroinflammation 2006 3 27 doi 1742-2094-3-27 This article is available from http content 3 1 27 2006 Colton et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Microglia are associated with neuritic plaques in Alzheimer disease AD and serve as a primary component of the innate immune response in the brain. Neuritic plaques are fibrous deposits composed of the amyloid beta-peptide fragments Abeta of the amyloid precursor protein APP . Numerous studies have shown that the immune cells in the vicinity of amyloid deposits in AD express mRNA and proteins for pro-inflammatory cytokines leading to the hypothesis that microglia demonstrate classical Th-1 immune activation in AD. Nonetheless the complex role of microglial activation has yet to be fully explored since recent studies show that

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