tailieunhanh - Báo cáo y học: " CD4 count at presentation for HIV care in the United States and Canada: Are those over 50 years more likely to have a delayed presentation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: CD4 count at presentation for HIV care in the United States and Canada: Are those over 50 years more likely to have a delayed presentation. | Althoff et al. AIDS Research and Therapy 2010 7 45 http content 7 1 45 AIDS RESEARCH AND THERAPY SHORT REPORT Open Access CD4 count at presentation for HIV care in the United States and Canada Are those over 50 years more likely to have a delayed presentation Keri N Althoff1 Kelly A Gebo2 Stephen J Gange1 Marina B Klein3 John T Brooks4 Robert S Hogg5 Des I Z I D r h6 A I_I rl-vz rzi 7 h I 1 c Z i 8 IXỈ - h- - 9 I z r z I c r 18 z I l I s -SI V- I lz10 Ronald J Bosch Michael A Horberg Michael S saag Mari M Kitahata Joseph J tron Sonia Napravnik Sean B Rourke11 M John Gill12 Benigno Rodriguez13 Timothy R Sterling14 Steven G Deeks15 Jeffrey N Martin16 1 1 9 17 7 18 Lisa P Jacobson Gregory D Kirk Ann C Collier Constance A Benson Michael J Silverberg James J Goedert Rosemary G McKaig19 Jennifer Thorne20 Anita Rachlis21 Richard D Moore2 Amy C Justice22 for the North American AIDS Cohort Collaboration on Research and Design Abstract We assessed CD4 count at initial presentation for HIV care among 50-year-olds from 1997-2007 in 13 US and Canadian clinical cohorts and compared to 50-year-olds. 44 491 HIV-infected individuals in the North American AIDS Cohort Collaboration on Research and Design NA-ACCORD were included in our study. Trends in mean CD4 count measured as cells mm3 and 95 confidence intervals were determined using linear regression stratified by age category and adjusted for gender race ethnicity HIV transmission risk and cohort. From 1997-2007 the proportion of individuals presenting for HIV care who were 50-years-old increased from 17 to 27 p-value . The median CD4 count among 50 year-olds was consistently lower than younger adults. The interaction of age group and calendar year was significant p-value with both age groups experiencing modest annual improvements over time 50-year-olds 5 4 6 cells mm3 50-year-olds 7 5 9 cells mm3 after adjusting for sex race ethnicity HIV transmission risk group and cohort however increases in