tailieunhanh - Báo cáo y học: " Multi-analyte profiling of ten cytokines in South African HIV-infected patients with Immune Reconstitution Inflammatory Syndrome (IRIS)"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Multi-analyte profiling of ten cytokines in South African HIV-infected patients with Immune Reconstitution Inflammatory Syndrome (IRIS). | Worsley et al. AIDS Research and Therapy 2010 7 36 http content 7 1 36 AIDS RESEARCH AND THERAPY RESEARCH Open Access Multi-analyte profiling of ten cytokines in South African HIV-infected patients with Immune Reconstitution Inflammatory Syndrome IRIS 1 1 1 2 Catherine M Worsley Melinda S Suchard Wendy S Stevens Annelies Van Rie David M Murdoch Abstract Background Immune reconstitution inflammatory syndrome IRIS is an important complication of HAART in subSaharan Africa where opportunistic infections OIs including mycobacteria and cryptococcus are common. The immune system s role in HIV infected patients is complex with cytokine expression strongly influencing HIV infection and replication. Methods We determined the expression patterns of 10 cytokines by Luminex multi-analyte profiling in 17 IRIS nested case-control pairs participating in a prospective South African cohort initiating anti-retroviral therapy. Results Interferon-gamma IFN-y expression was significantly elevated in IRIS cases compared to controls median pg ml versus pg ml respectively P while other cytokines displayed non-significant differences in expression. Significant correlation was observed between IL-6 IL-10 and IFN-y expression in the IRIS patients. Conclusions Significantly increased expression levels of IFN-y suggest that this cytokine possibly plays a role in IRIS pathology and is a potential diagnostic marker. Background HIV infection leads to a progressive loss of CD4 T cells and eventually to the onset of AIDS 1 . Highly active antiretroviral therapy HAART results in a dramatic reduction in AIDS-defining illnesses and mortality by inhibiting HIV replication with the subsequent recovery of CD4 T cell numbers and the restoration of immune function 2-4 . Some patients experience immune reconstitution inflammatory syndrome IRIS or immune restoration disease IRD as a result of pathological responses induced during immune restoration following the .