tailieunhanh - Muscle Functions in Polymyalgia Rheumatica and Giant-Cell Arteritis

This paper concerns primarily the elderly who live in congregate care settings, including independent living, assisted living, long term care, or continuing care retirement communities (CCRF). Concern for quality of life of older residents must today, more than ever before, include intensive planning and preparation for emergencies and disasters that would compromise the safety of our most at-risk elderly. As a striking example from Hurricane Katrina, of the 1330 deaths, nearly half of the victims were over 75 years of age, and approximately 71% of those who died were over 60 years of age (AARP 2006) | Healthy Aging Clinical Care in the Elderly Libertas Academica FREEDOM TO RESEARCH ORIGINAL RESEARCH OPEN ACCESS Full open access to this and thousands of other papers at http . Muscle Functions in Polymyalgia Rheumatica and Giant-Cell Arteritis Mikko P. Bjorkman and Reijo S. Tilvis Clinics of Internal Medicine and Geriatrics Helsinki University Central Hospital POB 340 FI-00290 HUS Helsinki Finland. Corresponding author email Abstract Objectives To find out whether and to what extent the muscle functions are impaired in polymyalgia rheumatica PMR patients in relation to duration activity and treatment of the disease as well as any history of giant cell-arteritis GCA . Methods Comprehensive clinical examinations of PMR patients N 40 called to participate in a clinical rehabilitation trial included among others the polymyalgia rheumatica disease activity score PMR-AS cytokine profile appendicular fat aFMI and muscle mass indices aMMI by dual X-ray absorbtiometry mean hand grip strength of both hands HGS and force platform countermovement jump height CJH . Results Of the older PMR patients years five had a history of GCA. Neither aMMI nor aFMI was associated with age in these patients. The HGS correlated moderately with CJH r P . In multivariate regression analyses old age P low aMMI P and high aFMI P were independently associated with weak HGS explaining R2 of its variation. Older age P lower aMMI P and higher aFMI P also independently indicated lower CJH explaining R2 of its variation. Muscle functions did not associate with disease characteristics of PMR or any history of GCA. Conclusions Low muscle mass and adiposity are the most important determinants of impaired muscle function and are a target for prevention in older patients suffering from PMR. Keywords polymyalgia rheumatic giant cell-arteritis muscle mass appendicular fat Healthy Aging .