tailieunhanh - Báo cáo y học: "Specific eradication of HIV-1 from infected cultured cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Specific eradication of HIV-1 from infected cultured cells. | Levin et al. AIDS Research and Therapy 2010 7 31 http content 7 1 31 AIDS RESEARCH AND THERAPY SHORT REPORT Open Access Specific eradication of HIV-1 from infected cultured cells 1 2 2 1 Aviad Levin Zvi Hayouka Assaf Friedler Abraham Loyter Abstract A correlation between increase in the integration of Human Immunodeficiency virus-1 HIV-1 cDNA and cell death was previously established. Here we show that combination of peptides that stimulate integration together with the protease inhibitor Ro 31-8959 caused apoptotic cell death of HIV infected cells with total extermination of the virus. This combination did not have any effect on non-infected cells. Thus it appears that cell death is promoted only in the infected cells. It is our view that the results described in this work suggest a novel approach to specifically promote death of HIV-1 infected cells and thus may eventually be developed into a new and general anti-viral therapy. Findings No cure or vaccine are currently available for the human immunodeficiency virus type 1 HIV-1 infection as well as for the resulting Acquired Immunodeficiency syndrome AIDS 1 . However an highly active antiretroviral therapy HAART which blocks the activities of the viral reverse transcriptase and protease and inhibits the virus-host fusion process is presently used 2 3 . The HAART transforms the infection process into a chronic disease 4-6 . Furthermore the risk of infection can significantly be reduced if the HAART treatment is given right after exposure to the virus 7 . New therapeutic approaches and new anti-viral inhibitors are being continuously developed to obtain a better restriction of the HIV-1 infection process 8-19 . However once the viral cDNA is integrated into the host chromosome it is almost impossible to terminate infection process and cure AIDS. A way to eradicate the integrated viral cDNA from virus infected cells by stimulating the viral Integrase IN mediated disintegration process was .