tailieunhanh - Báo cáo y học: " The impact of Highly Active Antiretroviral Therapy (HAART) on the clinical features of HIV - related oral lesions in Niger"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: The impact of Highly Active Antiretroviral Therapy (HAART) on the clinical features of HIV - related oral lesions in Nigeri. | Taiwo and Hassan AIDS Research and Therapy 2010 7 19 http content 7 1 19 AIDS RESEARCH AND THERAPY RESEARCH Open Access The impact of Highly Active Antiretroviral Therapy HAART on the clinical features of HIV - related oral lesions in Nigeria Olaniyi OTaiwo 1 and Zuwaira Hassan2 Abstract Background This study aimed to determine the therapeutic effects of highly active anti-retroviral therapy HAART on the clinical presentations of HIV related oral lesions HIV-ROLs in an adult Nigerian population. Methods A 5 month prospective study on HAART naive HIV positive adults recruited into the HAART program of an AIDS referral centre. HIV-ROLs were diagnosed clinically by the EEC Clearinghouse on oral problems related to HIV infection. Baseline clinical features of HIV-ROLs was documented by clinical photographs using SONY M Cybershot digital camera. Post HAART monthly review was conducted using clinical photographs. Results A total of 142 patients were seen. Age range was 19 - 75 years. Mean age was SD . Eighty were females. Prevalence of HIV-ROLs was . Oral candidiasis was the most prevalent HIV-ROL. 114 patients had clinical AIDS at presentation CDC 1993 . were placed on Tenofovir Emtricitabine Nevirapine on Tenofovir Emtricitabine Efavirenz. There was strong decline in the clinical features of oral candidiasis from a month of commencing HAART. Oral hairy leukoplakia was slow in responding to HAART. Parotid gland enlargement melanotic hyperpigmentation and Kaposi s sarcoma were more persistent and had slower response to HAART. There was no clinical change noticed in linear gingival erythema. Conclusion HAART has different clinical effects on HIV related oral lesions depending on the size duration of treatment and etiology of the lesions. HIV-ROLs of fungal origin have the fastest response to HAART. These lesions alongside immunologic parameters can be used as indicators of success or failure of .