tailieunhanh - Báo cáo y học: "Antiretroviral treatment adherence and its determinants in Sub-Saharan Africa: a prospective study at Yaounde Central Hospital, Cameroon"

Antiretroviral treatment adherence and its determinants in Sub-Saharan Africa: a prospective study at Yaounde Central Hospital, Cameroon | AIDS Research and Therapy BioMed Central Research Antiretroviral treatment adherence and its determinants in Sub-Saharan Africa a prospective study at Yaounde Central Hospital Cameroon Mathieu Rougemont 1 Beat E Stoll1 Nadia Elia1 and Peter Ngang2 Open Access Address Institute of Social and Preventive Medicine CMU CH-1211 Geneva 4 Switzerland and 2Department of Internal Medicine CNPS Hospital Yaounde Cameroon Email Mathieu Rougemont - redmat22@ Beat E Stoll - Nadia Elia - Peter Ngang - ngangbmvr@ Corresponding author Published 12 October 2009 Received 30 March 2009 AIDS Research and Therapy 2009 6 21 doi l742-6405-6-2l Accepted 12 October 2009 This article is available from http content 6 l 2l 2009 Rougemont et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background With African health-care systems facing exploding demand for HIV care reliable methods for assessing adherence and its influencing factors are needed to guide effective public-health measures. This study evaluated individual patient characteristics determining antiretroviral treatment ART adherence and the predictive values of different measures of adherence on virological treatment failure in a cohort of patients in a routine-care setting in Cameroon. Methods Longitudinal study over 6-months following ART introduction using patients questionnaires and hospital and pharmacy records. Results At the end of the 6 months study period 219 of 312 patients 70 returned to the pharmacy to refill their medication 17 51 were lost to follow-up 9 28 were dead and 4 14 were transferred to other care centres. Virological treatment failure at 6 months was experienced by .