tailieunhanh - Báo cáo y học: "Is vitamin D deficiency involved in the immune reconstitution inflammatory syndrome?"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Is vitamin D deficiency involved in the immune reconstitution inflammatory syndrome? | AIDS Research and Therapy BioMed Central Open Access Is vitamin D deficiency involved in the immune reconstitution inflammatory syndrome Anali Conesa-Botella 1 3 Chantal Mathieu2 Robert Colebunders1 3 Rodrigo Moreno-Reyes4 Evelyne van Etten2 Lut Lynen1 and Luc Kestens5 Address 1Institute of Tropical Medicine Department of Clinical Sciences Antwerp Belgium 2Katholieke Universiteit Leuven Laboratory of Experimental Medicine and Endocrinology Leuven Belgium 3University of Antwerp Faculty of Medicine Antwerp Belgium 4Université Libre de Bruxelles Department of Nuclear Medicine Brussels Belgium and institute of Tropical Medicine Department of Immunology Antwerp Belgium Email Anali Conesa-Botella - aconesa@ Chantal Mathieu - Robert Colebunders - bcoleb@ Rodrigo Moreno-Reyes - rmorenor@ Evelyne van Etten - Lut Lynen - Llynen@ Luc Kestens - LKestens@ Corresponding author Published 21 April 2009 Received 13 February 2009 AIDS Research and Therapy 2009 6 4 doi 1742-6405-6-4 Accepted 21 April 2009 This article is available from http content 6 1 4 2009 Conesa-Botella et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background About 20-30 of persons with HIV infection especially those living in countries with limited resources experience an immune reconstitution inflammatory syndrome IRIS after starting antiretroviral treatment. The active form of vitamin D 1 25-dihydroxyvitamin D is a key player in the clearance of pathogens and influences the level of inflammation and macrophage activation. Presentation of the hypothesis We hypothesize that low availability of 1 25-dihydroxyvitamin D either due