tailieunhanh - Báo cáo y học: " Resveratrol retards progression of diabetic nephropathy through modulations of oxidative stress, proinflammatory cytokines, and AMP-activated protein kinase"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Resveratrol retards progression of diabetic nephropathy through modulations of oxidative stress, proinflammatory cytokines, and AMP-activated protein kinase | Chang et al. Journal of Biomedical Science 2011 18 47 http content 18 1 47 tì NSC The cost of publication in Journal of Biomedical Science Is borne by the National Science Council Taiwan JOURNAL OF BIOMEDICAL SCIENCE RESEARCH Open Access Resveratrol retards progression of diabetic nephropathy through modulations of oxidative stress proinflammatory cytokines and AMP-activated protein kinase Chih-Chun Chang1 Chieh-Yu Chang1 Yang-Tzu Wu1 Jiung-Pang Huang1 Tzung-Hai Yen2 and Li-Man Hung1 Abstract Background Diabetic nephropathy DN has been recognized as the leading cause of end-stage renal disease. Resveratrol RSV a polyphenolic compound has been indicated to possess an insulin-like property in diabetes. In the present study we aimed to investigate the renoprotective effects of RSV and delineate its underlying mechanism in early-stage DN. Methods The protective effects of RSV on DN were evaluated in streptozotocin STZ -induced diabetic rats. Results The plasma glucose creatinine and blood urea nitrogen were significantly elevated in STZ-induced diabetic rats. RSV treatment markedly ameliorated hyperglycemia and renal dysfunction in STZ-induced diabetic rats. The diabetes-induced superoxide anion and protein carbonyl levels were also significantly attenuated in RSV-treated diabetic kidney. The AMPK protein phosphorylation and expression levels were remarkably reduced in diabetic renal tissues. In contrast RSV treatment significantly rescued the AMPK protein expression and phosphorylation compared to non-treated diabetic group. Additionally hyperglycemia markedly enhanced renal production of proinflammatory cytokine IL-1p. RSV reduced IL-1P but increased TNF-a and IL-6 levels in the diabetic kidneys. Conclusions Our findings suggest that RSV protects against oxidative stress exhibits concurrent proinflammation and anti-inflammation and up-regulates AMPK expression and activation which may contribute to its beneficial effects on the early stage of DN. .