tailieunhanh - Báo cáo y học: "Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protection"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protection | Ho and Hong Journal of Biomedical Science 2011 18 30 http content 18 1 30 The cost of publication in Journal of Biomedical Science Is borne by the National Science Council Taiwan JOURNAL OF BIOMEDICAL SCIENCE REVIEW Open Access Salvianolic acids small compounds with multiple mechanisms for cardiovascular protection Jennifer Hui-Chun Ho1 2 3 and Chuang-Ye Hong1 4 Abstract Salvianolic acids are the most abundant water-soluble compounds extracted from Radix Salvia miltiorrhiza Danshen . In China Danshen has been wildly used to treat cardiovascular diseases for hundreds of years. Salvianolic acids especially salvianolic acid A Sal A and salvianolic acid B Sal B have been found to have potent anti-oxidative capabilities due to their polyphenolic structure. Recently intracellular signaling pathways regulated by salvianolic acids in vascular endothelial cells aortic smooth muscle cells as well as cardiomyocytes have been investigated both in vitro and in vivo upon various cardiovascular insults. It is discovered that the cardiovascular protection of salvianolic acids is not only because salvianolic acids act as reactive oxygen species scavengers but also due to the reduction of leukocyte-endothelial adherence inhibition of inflammation and metalloproteinases expression from aortic smooth muscle cells and indirect regulation of immune function. Competitive binding of salvianolic acids to target proteins to interrupt protein-protein interactions has also been found to be a mechanism of cardiovascular protection by salvianolic acids. In this article we review a variety of studies focusing on the above mentioned mechanisms. Besides the target proteins of salvianolic acids are also described. These results of recent advances have shed new light to the development of novel therapeutic strategies for salvianolic acids to treat cardiovascular diseases. Introduction Salvianolic acid is one of the bioactive compounds of S. miltiorrhiza BGE extracted from .