tailieunhanh - Báo cáo y học: " HIV-1 transgene expression in rats causes oxidant stress and alveolar epithelial barrier dysfunction"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: HIV-1 transgene expression in rats causes oxidant stress and alveolar epithelial barrier dysfunction. | AIDS Research and Therapy BioMed Central Research HIV-1 transgene expression in rats causes oxidant stress and alveolar epithelial barrier dysfunction Coy Lassiter1 2 Xian Fan1 2 Pratibha C Joshi1 2 Barbara A Jacob1 2 Roy L Sutliff1 2 Dean P Jones1 Michael Koval1 and David M Guidot 1 2 Open Access Address Department of Medicine Division of Pulmonary Allergy and Critical Care Medicine Emory University School of Medicine Atlanta Georgia USA and 2The Section of Pulmonary and Critical Care Medicine Atlanta VA Medical Center Decatur Georgia USA Email Coy Lassiter - coylassiter@ Xian Fan - xfan@ Pratibha C Joshi - pcjoshi@ Barbara AJacob - bajacob74@ Roy LSutliff- rsutlif@ Dean P Jones - dpjones@ Michael Koval - mhkoval@ David M Guidot - dguidot@ Corresponding author Published 4 February 2009 Received 9 September 2008 AIDS Research and Therapy 2009 6 1 doi 1742-6405-6-1 Accepted 4 February 2009 This article is available from http content 6 1 1 2009 Lassiter et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background HIV-infected individuals are at increased risk for acute and chronic airway disease even though there is no evidence that the virus can infect the lung epithelium. Although HIV-related proteins including gp120 and Tat can directly cause oxidant stress and cellular dysfunction their effects in the lung are unknown. The goal of this study was to determine the effects of HIV-1 transgene expression in rats on alveolar epithelial barrier function. Alveolar epithelial barrier function was assessed by determining lung liquid .