tailieunhanh - Báo cáo y học: "Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways. | AIDS Research and Therapy BioMed Central Open Access Two specific drugs BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways Emmanuel Agbottah1 Wen-I Yeh1 Reem Berro1 Zachary Klase1 Caitlin Pedati1 Kyelne Kehn-Hall1 Weilin Wu1 and Fatah Kashanchi 1 2 3 Address Department of Microbiology and tropical Medicine and Department of Biochemistry and Molecular Biology The George Washington University School of Medicine Washington District of Columbia 20037 USA 2Department of Microbiology Institute for Proteomics Technology and Applications The George Washington University Washington District of Columbia 20037 USA and 3The Institute for Genomic Research TIGR Rockville Maryland 20850 USA Email Emmanuel Agbottah - bcmeta@ Wen-I Yeh - jennyyeh@ Reem Berro - ramroom@ Zachary Klase - bcmzak@ Caitlin Pedati - bcmcsp@ Kyelne Kehn-Hall - bcmkwk@ Weilin Wu - bcmwxw@ Fatah Kashanchi - bcmfxk@ Corresponding author Published 10 June 2008 Received 28 November 2007 AIDS Research and Therapy 2008 5 12 doi l742-6405-5-l2 Accepted I0 June 2008 This article is available from http content 5 l l2 2008 Agbottah et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Human T-cell leukemia virus type-l HTLV-l induces adult T-cell leukemia lymphoma ATL L a fatal lymphoproliferative disorder and HTLV-l-associated myelopathy tropical spastic paraparesis HAM TSP a chronic progressive disease of the central nervous system after a long period of latent infection. Although the mechanism of transformation and leukemogenesis is not fully elucidated there is evidence to suggest that