tailieunhanh - Báo cáo y học: "Summary of presentations at the NIH/NIAID New Humanized Rodent Models 2007 Workshop"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Summary of presentations at the NIH/NIAID New Humanized Rodent Models 2007 Workshop. | AIDS Research and Therapy BioMed Central Open Access Review Summary of presentations at the NIH NIAID New Humanized Rodent Models 2007 Workshop Harris Goldstein Address Departments of Pediatrics and Microbiology Immunology Albert Einstein College of Medicine Bronx New York 10461 USA Email Harris Goldstein - hgoldste@ Published 31 January 2008 AIDS Research and Therapy 2008 5 3 doi 1742-6405-5-3 Received 19 December 2007 Accepted 31 January 2008 This article is available from http content 5 1 3 2008 Goldstein licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract It has long been recognized that a small animal model susceptible to HIV-1 infection with a functional immune system would be extremely useful in the study of HIV AIDS pathogenesis and for the evaluation of vaccine and therapeutic strategies to combat this disease. By early 2007 a number of reports on various rodent models capable of being infected by and responding to HIV including some with a humanized immune system were published. The New Humanized Rodent Model Workshop organized by the Division of AIDS DAIDS National Institute Allergy and Infection Diseases NIAID NIH was held on September 24 2007 at Bethesda for the purpose of bringing together key model developers and potential users. This report provides a synopsis of the presentations that discusses the current status of development and use of rodent models to evaluate the pathogenesis of HIV infection and to assess the efficacy of vaccine and therapeutic strategies including microbicides to prevent and or treat HIVinfection. Introduction Investigation of many aspects of the in vivo behavior of HIV as well as testing of the in vivo efficacy of novel antiHIV .