tailieunhanh - Báo cáo y học: " Protease inhibitor associated mutations compromise the efficacy of therapy in human immunodeficiency virus – 1 (HIV-1) infected pediatric patients: a cross-sectional study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Protease inhibitor associated mutations compromise the efficacy of therapy in human immunodeficiency virus – 1 (HIV-1) infected pediatric patients: a cross-sectional study. | AIDS Research and Therapy BioMed Central Open Access Protease inhibitor associated mutations compromise the efficacy of therapy in human immunodeficiency virus - 1 HIV-1 infected pediatric patients a cross-sectional study Amisha Malhotra 1 Sunanda Gaur1 Patricia Whitley-Williams1 Caitlin Loomis2 and Anna Petrova1 Address Department of Pediatrics Division of Infectious Disease University of Medicine and Dentistry of New Jersey UMDNJ - Robert Wood Johnson Medical School New Brunswick New Jersey 08903 USA and 2Princeton University Princeton New Jersey-08542 USA Email Amisha Malhotra - malhotam@ Sunanda Gaur - gaursu@ Patricia Whitley-Williams - whitlepn@ Caitlin Loomis - Anna Petrova - petroran@ Corresponding author Published 9 July 2007 Received 30 October 2006 AIDS Research and Therapy 2007 4 15 doi 1742-6405-4-15 Accepted 9 July 2007 This article is available from http content 4 1 15 2007 Malhotra et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Although the introduction of combined therapy with reverse transcriptase and protease inhibitors has resulted in considerable decrease in HIV related mortality it has also induced the development of multiple drug-resistant HIV-1 variants. The few studies on HIV-1 mutagenesis in HIV infected children have not evaluated the impact of HIV-1 mutations on the clinical virological and immunological presentation of HIV disease that is fundamental to optimizing the treatment regimens for these patients. Results A cross sectional study was conducted to evaluate the impact of treatment regimens and resistance mutation patterns on the clinical virological and immunological .