tailieunhanh - Báo cáo y học: "HLA-G DNA sequence variants and risk of perinatal HIV-1 transmission"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: HLA-G DNA sequence variants and risk of perinatal HIV-1 transmission. | AIDS Research and Therapy BioMed Central Research HLA-G DNA sequence variants and risk of perinatal HIV-I transmission Felix O Aikhionbare 1 K Kumaresan1 Falah Shamsa2 and Vincent C Bond3 Open Access Address Department of Medicine Morehouse School of Medicine Atlanta GA 30310 USA 2Department of Community Health and Preventive Medicine Morehouse School of Medicine Atlanta GA 30310 USA and 3Department of Microbiology Biochemistry Immunology Morehouse School of Medicine Atlanta GA 30310 USA Email Felix O Aikhionbare - faikhionbare@ K Kumaresan - kkumaresan@ Falah Shamsa - fshamsa@ Vincent C Bond - vbond@ Corresponding author Published 23 October 2006 Received 19 June 2006 AIDS Research and Therapy 2006 3 28 doi l742-6405-3-28 Accepted 23 October 2006 This article is available from http content 3 1 28 2006 Aikhionbare et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background HLA-G gene is a non-classical MHC class 1 molecule that is highly expressed in the trophoblast at the maternal-fetal interface. In an attempt to elucidate possible immunological mechanisms facilitating protection of infants born to human immunodeficiency virus type HIV-1 infected mothers we have been studying genetic variations in the coding and untranslated regions of HLA-G antigen between HIV-1-infected mothers and their infected or uninfected infants. This study investigated whether HLA-G DNA sequence variants are associated with perinatal HIV-1 transmission. Results Genomic DNA samples were obtained from a nested case-control study of 34 motherchild pairs co-enrolled in a cohort of the Perinatal .