tailieunhanh - Báo cáo y học: "Predicting AIDS-related events using CD4 percentage or CD4 absolute counts"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Predicting AIDS-related events using CD4 percentage or CD4 absolute counts. | AIDS Research and Therapy BioMed Central Research Predicting AIDS-related events using CD4 percentage or CD4 absolute counts Yasmin Pirzada Sadik Khuder and Haig Donabedian Open Access Address College of Medicine University of Toledo Department of Internal Medicine 3120 Glendale Ave Toledo OH 43614 USA Email Yasmin Pirzada - idypirzada@ Sadik Khuder - skhuder@ Haig Donabedian - hdonabedian@ Corresponding author Published 17 August 2006 Received 05 May 2006 AIDS Research and Therapy 2006 3 20 doi l742-6405-3-20 Accepted 17 August 2006 This article is available from http content 3 1 20 2006 Pirzada et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The extent of immunosuppression and the probability of developing an AIDS-related complication in HIV-infected people is usually measured by the absolute number of CD4 positive T-cells. The percentage of CD4 positive cells is a more easily measured and less variable number. We analyzed sequential CD4 and CD8 numbers percentages and ratios in 218 of our HIV infected patients to determine the most reliable predictor of an AIDS-related event. Results The CD4 percentage was an unsurpassed predictor of the occurrence of AIDS-related events when all subsets of patients are considered. The CD4 absolute count was the next most reliable followed by the ratio of CD4 CD8 percentages. The value of CD4 percentage over the CD4 absolute count was seen even after the introduction of highly effective HIV therapy. Conclusion The CD4 percentage is unsurpassed as a parameter for predicting the onset of HIV-related diseases. The extra time and expense of measuring the CD4 absolute count may be unnecessary. Background