tailieunhanh - Báo cáo y học: "The effect of different combination therapies on oxidative stress markers in HIV infected patients in cameroon"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: The effect of different combination therapies on oxidative stress markers in HIV infected patients in cameroon. | AIDS Research and Therapy BioMed Central Research The effect of different combination therapies on oxidative stress markers in HIV infected patients in Cameroon Judith L Ngondi 1 Julius Oben1 David Musoro Forkah1 Lucein Honore Etame1 and Dora Mbanya2 Open Access Address Nutrition HIV and Health Research Unit Department of Biochemistry University of Yaounde I Cameroon and 2Faculty of Medicine and Biomedical Sciences University of Yaounde I Cameroon Email Judith LNgondi - jlngondi@ Julius Oben - juluisoben@ David Musoro Forkah - letame@ Lucein Honore Etame - dfmusoro@ Dora Mbanya - dmbanya@ Corresponding author Published 22 July 2006 Received 06 October 2005 AIDS Research and Therapy 2006 3 19 doi 1742-6405-3-19 Accepted 22 July 2006 This article is available from http content 3 1 19 2006 Ngondi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The study assessed the effect of some highly active antiretroviral therapies HAART used in the management of HIV AIDS in Cameroon on oxidative stress markers such as malondialdehyde as TBARs albumin protein carbonyl content and protein sulfhydryls groups. 85 HIV positive patients years were on three different highly active antiretroviral therapies HAART patients . 65 HIV positive patients years on no treatment Pre-HAART patients and 90 nonHIV infected patients years were the control groups. Plasma TBARs as well as carbonyl levels were significantly higher in HIV patients on HAART compared to pre-HAART patients or non-HIV infected controls. On the other hand the protein sulfhydryl group content was not different for patients on HAART compared to pre-HAART patients but