tailieunhanh - Báo cáo y học: "IL-2 production correlates with effector cell differentiation in HIV-specific CD8+ T cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: IL-2 production correlates with effector cell differentiation in HIV-specific CD8+ T cells. | AIDS Research and Therapy BioMed Central Research IL-2 production correlates with effector cell differentiation in HIV-specific CD8 T cells Laurel E Nomura 1 Brinda Emu2 Rebecca Hoh3 Perry Haaland4 Steven G Deeks3 Jeffrey N Martin3 5 Joseph M McCune2 Douglas F Nixon2 and Holden T Maecker1 Open Access Address 1BD Biosciences Immunocytometry Systems 2350 Qume Dr. San Jose CA 95131 USA 2Division of Experimental Medicine University of California San Francisco CA 94110 USA 3Department of Medicine San Francisco General Hospital University of California San Francisco CA 94110 USA 4BD Technologies 21 Davis Dr. Research Triangle Park NC 27709 USA and 5Department of Epidemiology and Biostatistics University of California San Francisco CA 94143 USA Email Laurel E Nomura - laurel_nomura@ Brinda Emu - Rebecca Hoh - rhoh@ Perry Haaland - perry_haaland@ Steven G Deeks - sdeeks@ Jeffrey N Martin - martin@ Joseph M McCune - Douglas F Nixon - Holden T Maecker - holden_maecker@ Corresponding author Published 21 July 2006 Received 24 April 2006 AIDS Research and Therapy 2006 3 18 doi 1742-6405-3-18 Accepted 21 July 2006 This article is available from http content 3 1 18 2006 Nomura et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Diminished IL-2 production and lack of effector differentiation have been reported for HIV-specific T cells. In this study we examined the prevalence of these phenomena using 8-color cytokine flow cytometry and tested the hypothesis that these two findings were causally related. We analyzed cytokine profiles and memory effector phenotypes of .

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