tailieunhanh - Báo cáo y học: "A nucleolar localizing Rev binding element inhibits HIV replication"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: A nucleolar localizing Rev binding element inhibits HIV replication. | AIDS Research and Therapy BioMed Central Research Open Access A nucleolar localizing Rev binding element inhibits HIV replication Alessandro Michienzi1 3 Fernanda G De Angelis2 Irene Bozzoni2 and John J Rossi 1 4 Address 1Division of Molecular Biology Beckman Research Institute of the City of Hope 1450 East Duarte Rd. Duarte California 91010 USA 2Istituto Pasteur Fondazione Cenci-Bolognetti Department of Genetics and Molecular Biology University of Rome La Sapienza and IBPM of CNR Rome Italy 3Present address Istituto Superiore di Sanita Department of Cell Biology and Neuroscience Viale Regina Elena 299 00161 Rome Italy and 4Division of Molecular Biology Graduate School of Biological Sciences Beckman Research Institute of the City of Hope 1450 E. Duarte Rd. Duarte CA 91010 USA Email Alessandro Michienzi - amichienzi@ Fernanda G De Angelis - Irene Bozzoni - John J Rossi - jrossi@ Corresponding author Published 19 May 2006 Received 08 February 2006 AIDS Research and Therapy 2006 3 13 doi l742-6405-3-l3 Accepted 19 May 2006 This article is available from http content 3 l l 3 2006 Michienzi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The Rev protein of the human immunodeficiency virus HIV facilitates the nuclear export of intron containing viral mRNAs allowing formation of infectious virions. Rev traffics through the nucleolus and shuttles between the nucleus and cytoplasm. Rev multimerization and interaction with the export protein CRMl takes place in the nucleolus. To test the importance of Rev nucleolar trafficking in the HIV-l replication cycle we created a nucleolar localizing Rev Response Element RRE .