tailieunhanh - Báo cáo y học: "Cerebrospinal fluid signs of neuronal damage after antiretroviral treatment interruption in HIV-1 infectio"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Cerebrospinal fluid signs of neuronal damage after antiretroviral treatment interruption in HIV-1 infection. | AIDS Research and Therapy BioMed Central Research Open Access Cerebrospinal fluid signs of neuronal damage after antiretroviral treatment interruption in HIV-1 infection Magnus Gisslén 1 Lars Rosengren2 Lars Hagberg1 Steven G Deeks3 and Richard W Price4 Address Department of Infectious Diseases Gõteborg University Sahlgrenska University Hospital Sweden 2Department of Neurology Gõteborg University Sahlgrenska University Hospital Sweden 3Department of Medicine University of California San Francisco San Francisco General Hospital CA USA and 4Department of Neurology University of California San Francisco San Francisco General Hospital CA USA Email Magnus Gisslén - Lars Rosengren - Lars Hagberg - Steven G Deeks - sdeeks@ Richard W Price - price@ Corresponding author Published 18 August 2005 Received 06 June 2005 AIDS Research and Therapy 2005 2 6 doi 1742-6405-2-6 Accepted 18 August 2005 This article is available from http content 2 1 6 2005 Gisslén et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The neurofilament is a major structural component of myelinated axons. Increased cerebrospinal fluid CSF concentrations of the light chain of the neurofilament protein NFL can serve as a sensitive indicator of central nervous system CNS injury. To assess whether interrupting antiretroviral treatment of HIV infection might have a deleterious effect on the CNS we measured NFL levels in HIV-infected subjects interrupting therapy. We identified subjects who had CSF HIV RNA concentrations below 50 copies mL at the time combination antiretroviral therapy was interrupted and for whom