tailieunhanh - Báo cáo y học: "Vitamin supplementation for prevention of mother-to-child transmission of HIV and pre-term delivery: a systematic review of randomized trial including more than 2800 women"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Vitamin supplementation for prevention of mother-to-child transmission of HIV and pre-term delivery: a systematic review of randomized trial including more than 2800 women. | AIDS Research and Therapy BioMed Central Research Open Access Vitamin supplementation for prevention of mother-to-child transmission of HIV and pre-term delivery a systematic review of randomized trial including more than 2800 women Edward J Mills 1 Ping Wu2 3 Dugald Seely3 4 and Gordon H Guyatt1 Address Department of Clinical Epidemiology Biostatistics McMaster University Hamilton Canada 2London School of Hygiene Tropical Medicine London UK 3Division of Clinical Epidemiology Canadian College Of Naturopathic Medicine Toronto Canada and 4Hospital for Sick Children University of Toronto Toronto Canada Email Edward J Mills - millsej@ Ping Wu - pwu@ Dugald Seely - dseely@ Gordon H Guyatt - guyatt@ Corresponding author Published 06 May 2005 Received 20 January 2005 AIDS Research and Therapy 2005 2 4 doi l 742-6405-2-4 Accepted 06 May 2005 This article is available from http content 2 1 4 2005 Mills et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Observational studies have suggested that low serum vitamin levels are associated with increased mother-to-child transmission MTCT of HIV and increased preterm delivery. We aimed to determine the efficacy of vitamins on the prevention of MTCT and preterm delivery by systematically reviewing the available randomized controlled trials RCTs . We conducted systematic searches of 7 electronic databases. We extracted data from the RCTs independently in duplicate. Results We included 4 trials in our review. Of the three trials on Vitamin A two suggested no difference in MTCT while the third and largest trial n l078 suggested an increased risk of MTCT Relative Risk 95 Confidence Interval CI .