tailieunhanh - Region-specific effects on brain metabolites of hypoxia and hyperoxia overlaid on cerebral ischemia in young and old rats: a quantitative proton magnetic resonance spectroscopy stud

Both hypoxia and hyperoxia, deregulating the oxidative balance, may play a role in the pathology of neurodegenerative disorders underlain by cerebral ischemia. In the present study, quantitative proton magnetic resonance spectroscopy was used to evaluate regional metabolic alterations, following a 24-hour hypoxic or hyperoxic exposure on the background of ischemic brain insult, in two | Macri et al. Journal of Biomedical Science 2010 17 14 http content 17 1 14 I NSC The cost of publication in Journal of Biomedical Science is bourne by the National Science Council Taiwan. JOURNAL OF BIOMEDICAL SCIENCE RESEARCH Open Access Region-specific effects on brain metabolites of hypoxia and hyperoxia overlaid on cerebral ischemia in young and old rats a quantitative proton magnetic resonance spectroscopy study Maria A Macri1 Nicola DAlessandro2 Camillo Di Giulio3 Patrizia Di Iorio4 Silvano Di Luzio5 Patricia Giuliani4 Ennio Esposito6 and Mieczyslaw Pokorski 7 Abstract Background Both hypoxia and hyperoxia deregulating the oxidative balance may play a role in the pathology of neurodegenerative disorders underlain by cerebral ischemia. In the present study quantitative proton magnetic resonance spectroscopy was used to evaluate regional metabolic alterations following a 24-hour hypoxic or hyperoxic exposure on the background of ischemic brain insult in two contrasting age-groups of rats young - 3 months old and aged - 24 months old. Methods Cerebral ischemia was induced by ligation of the right common carotid artery. Concentrations of eight metabolites alanine choline-containing compounds total creatine Y-aminobutyric acid glutamate lactate myoinositol and N-acetylaspartate were quantified from extracts in three different brain regions fronto-parietal and occipital cortices and the hippocampus from both hemispheres. Results In the control normoxic condition there were significant increases in lactate and myo-inositol concentrations in the hippocampus of the aged rats compared with the respective values in the young ones. In the ischemia-hypoxia condition the most prevalent changes in the brain metabolites were found in the hippocampal regions of both young and aged rats but the effects were more evident in the aged animals. The ischemia-hyperoxia procedure caused less dedicated changes in the brain metabolites which may reflect more limited

• Báo cáo khoa học
• statements and documents scientific reports
• medical reports
• medical knowledge
• medical research
• medical research
• health care
• Health careassociated infections
• Antimicrobial susceptibility testing
• Health care worker
• Tertiary care hospital
• Health care workers
• Staphylococcus aureus
• Methicillin resistance staphylococcus aureus
• Health care workers in a tertiary care center
• Prevalence of carriage
• Health care personnel
• Health care skills
• Phlebotomy for health care personnel
• History of Phlebotomy
• Regulatory agencies
• Infection control
• Blood circulation
• Coronary circulation
• Pulmonary circulation
• Specimen collection
• Equipment for specimen collection
• Laboratory requisitions
• Performing venipuncture
• Dermal puncture
• Patient positioning
• Specimen handling
• Specimen processing
• Blood cultures
• Special phlebotomy procedures
• Glucose testing
• Bleeding time procedure
• Phlebotomy continuing education
• Practicing phlebotomy
• Quality assurance in phlebotomy
• Service quality management on health care industry in Bangalore
• Health care industry in Bangalore
• Health care spending in America
• Larger share of GDP than
• Gross domestic produc
• Home Health Care
• Health Care Routing
• Simulated Annealing algorithm
• Staff vehicle traveling
• Health Care system
• Hepatitis B virus
• Anti HBs titre
• Hepatitis B vaccination
• Joint annual health review 2015
• Socio economic situation
• Strengthening primary health care
• Health coverage
• Grassroots health network
• BMC Pediatrics
• Immediate newborn care
• District health offices
• Regional health bureau
• Health facilities
• Economic management
• Summary of Economic dissertation
• Quality of health care services
• Health insurance at district hospitals
• Health care services
• Health financial burden
• Health care services of households
• Health expenditure
• Health insurance
• Basis health level
• Hospital fee
• Out of pocket
• Lecture Economics
• Demand analysis to health care
• Copayment rate
• Demand for health care
• Market equilibrium
• Summary of Doctoral thesis
• Public private partnership
• Providing health care services
• Application of PPP in the health care
• Public health
• Usual source of care
• Cardiovascular diseases
• Health care seeking
• CVD related health care
• Health information management
• Health care delivery systems
• Health information management professionals
• Health care settings
• Electronic health records
• The patient record
• Educational attainment levels
• Nontraditional health information resources
• Findings from the Canadian survey
• Experiences with primary health care
• Primary health care
• Mupirocin resistance
• Health care provider
• Nasal swab
• Health care providers with MRSA
• Nosocomial infections
• Bio medical waste
• Hand hygiene
• Health care associated infections
• geographical dimension
• time dimension
• mental illness
• health campaigns
• Health information technology
• Improve health
• care quality
• Prevent medical errors
• Reduce health care costs
• Increase administrative efficiencies
• Decrease paperwork
• affordable care