tailieunhanh - Biosensors Emerging Materials and Applications Part 13

Tham khảo tài liệu 'biosensors emerging materials and applications part 13', kỹ thuật - công nghệ, cơ khí - chế tạo máy phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | 472 Biosensors - Emerging Materials and Applications Ifosfamide Indinavir Midazolam Quinidine Progesterone Verapamil Anticancer and immunosuppressive Anti-HIV Anxiolytic anaesthetic sedative anticonvulsant and muscle relaxant Beta blocker Steroid hormone For the treatment of hypertension angina pectoris cardiac arrhythmia -435mV -750mV - - -100mV Ignaszak et al. 2009 Joseph et al. 2003 Joseph et al. 2003 Joseph et al. 2003 Joseph et al. 2003 Measurements obtained in studies performed by the authors immobilizing CYPs isoforms onto carbon nanotubes. Table 3. List of CYPs used for the detection of drugs for common diseases and their reduction potential obtained with cyclic voltammetry technique. analysis of reduction peaks obtained in the cyclic-voltammograms. The electron transfer can be enhanced by electrodes nanostructuring as using metallic or zirconium dioxide nanoparticles carbon-nanotubes Bistolas et al. 2005 Eggins 2003 or other techniques for the enzyme immobilization onto the electrode surface which have been already explained in the previous pharagraph. Different studies demonstrated that carbon-nanotubes schematized in figure 20 promote the electron transfer between the CYP active site and the electrode and enhance biosensor sensitivity Lyons Keeley 2008 Wang 2005 . In table 3 a list of a target drugs which have been detected with several CYP isoforms used as biological recognition element of biosensors is reported. So the cytochromes P450 may be used to detect drug compounds commonly used in medical treatments by using nanoparticles or carbon nanotubes for improving the device sensitivity to reach the therapeutic ranges found in the patients serum. Since for the treatments some of the most common diseases as in anti-cancer therapies more than one drug are administrated contemporaneously an array-based biosensor able to measure multipledrug concentrations at the same time by using different CYP isoforms would be very useful and it would find several .