tailieunhanh - Tropical Neurology - part 8

sinh tham số kích thước 2 mm-học sinh kích thước 20/min 20/min tỷ lệ hô hấp với các trung tâm xanh tím 4. Nhịp tim chậm nhịp tim 60/min-nhịp tim 41-60/min-nhịp tim | 374 Tropical Neurology Table . Peradeniya Organophosphorus Poisoning POP scale Parameter Score -pupil size 2 mm -pupil size 2 mm -pupils pin-point 0 1 2 -none -present but not generalized or continuous -generalized and continuous 0 1 2 3. Respiration -respiratory rate 20 rnin 0 -respiratory rate 20 min 1 -respiratory rate 20 min 2 with central cyanosis 4. Bradycardia -pulse rate 60 min 0 -pulse rate 41-60 min 1 -pulse rate 40 min 2 5. Level of consciousness -conscious and rational 0 -impaired responds to verbal commands 1 -impaired no response to verbal commands 2 if convulsions present add 1 TOTAL 11 Reproduced with permission from Hum Exp Toxicol 1993 12 297-299. asymmetrical. The delay in onset of these signs varied from four to 40 days and disappeared spontaneously in about one to four weeks in the patients who survived. The majority of cholinergic neurons in the human brain are localized in the striatum basal forebrain and mesencephalic and pontine reticular formation. AChE is widely distributed within some subcortical areas the nuclei richest are caudate and globus pallidus. Therefore it is conceivable that inhibition of AChE in these cholinergic neurons following OP intoxication may produce extrapyramidal manifestations. Fenthion a highly lipophilic dimethoxy compound has better access to central neurons because of its lipid Neurobehavioral Effects The most frequently reported symptoms following exposure to OPI include impaired memory and vigilance reduced information processing and psychomotor speed memory deficit linguistic disturbances depression anxiety and irritability. There is some concern that exposure to OP agents may precipitate psychosis. Electrical activity of the brain has been studied in workers exposed to sarin following a Insecticides and Industrial Poisons 375 Table . Comparison of the intermediate syndrome and the delayed neuropathy Delayed neuropathy 20 Variable Intermediate syndrome Time of .