tailieunhanh - Báo cáo y học: "Bringing order to protein disorder through comparative genomics and genetic interactions"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Bringing order to protein disorder through comparative genomics and genetic interactions. | Bellay et al. Genome Biology 2011 12 R14 http 2011 12 2 R14 Genome Biology RESEARCH Open Access Bringing order to protein disorder through comparative genomics and genetie interactions 1 23 23 234 Jeremy Bellay Sangjo Han Magali Michaut TaeHyung Kim Michael Costanzo Brenda J Andrews Charles Boone2 3 4 Gary D Bader2 3 4 5 Chad L Myers 1 2 and Philip M Kim2 3 4 5 Abstract Background Intrinsically disordered regions are widespread especially in proteomes of higher eukaryotes. Recently protein disorder has been associated with a wide variety of cellular processes and has been implicated in several human diseases. Despite its apparent functional importance the sheer range of different roles played by protein disorder often makes its exact contribution difficult to interpret. Results We attempt to better understand the different roles of disorder using a novel analysis that leverages both comparative genomics and genetic interactions. Strikingly we find that disorder can be partitioned into three biologically distinct phenomena regions where disorder is conserved but with quickly evolving amino acid sequences flexible disorder regions of conserved disorder with also highly conserved amino acid sequences constrained disorder and lastly non-conserved disorder. Flexible disorder bears many of the characteristics commonly attributed to disorder and is associated with signaling pathways and multi-functionality. Conversely constrained disorder has markedly different functional attributes and is involved in RNA binding and protein chaperones. Finally non-conserved disorder lacks clear functional hallmarks based on our analysis. Conclusions Our new perspective on protein disorder clarifies a variety of previous results by putting them into a systematic framework. Moreover the clear and distinct functional association of flexible and constrained disorder will allow for new approaches and more specific algorithms for disorder detection in a functional .