tailieunhanh - Báo cáo y học: "The Genomic HyperBrowser: inferential genomics at the sequence level"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: The Genomic HyperBrowser: inferential genomics at the sequence level. | The Genomic HyperBrowser inferential genomics at the sequence level Sandve et al. Sandve et al. Genome Biology 2010 11 R121 http 2010 11 12 R121 23 December 2010 BioMed Central Sandve et al. Genome Biology 2010 11 R121 http 2010 11 12 R121 Genome Biology SOFTWARE Open Access The Genomic HyperBrowser inferential genomics at the sequence level IX 0 z J Zz 1 c Zz 1 V I IV z ỉ L I I XI 1 2 I_I I fr l D Zz l I r I 1 3 5 I f- i VI I IX C I I4 I rr I_I I I z V 3 K I rit- I_I Z X I I 3 Geir K sanave sveinung Gunaersen Hairaan RyabecK Ingria K Giaa Lars noiaen Mam noiaen 1 5 2 3 5 5 6 Knut Liest0i Irevor Clancy Egii FerKingstaa Morten Johansen Vegara Nygaara Eivina lastesen Arnoiao Frigessi3 7 Eivina Hovig1 2 3 6 Abstract The immense increase in the generation of genomic scaie aata poses an unmet anaiyticai chaiienge aue to a iacK of estabiishea methoaoiogy with the requirea fiexibiiity ana power. We propose a first principiea approach to statisticai anaiysis of sequence-ievei genomic information. We proviae a growing coiiection of generic bioiogicai investigations that query pairwise reiations between tracks representea as mathematicai objects aiong the genome. The Genomic HyperBrowser impiements the approach ana is avaiiabie at http . Rationale The combination of high-throughput molecular techniques and deep DNA sequencing is now generating detailed genome-wide information at an unprecedented scale. As complete human genomic information at the detail of the ENCODE project 1 is being made available for the full genome it is becoming possible to query relations between many organizational and informational elements embedded in the DNA code. These elements can often best be understood as acting in concert in a complex genomic setting and research into functional information typically involves integrational aspects. The knowledge that may be derived from such analyses is however presently only harvested to a small degree.