tailieunhanh - TRITIUM AND OTHER RADIONUCLIDE LABELED ORGANIC COMPOUNDS INCORPORATED IN GENETIC MATERIAL

In 1968 the NCRP Board of Directors, in an expansion of its internal emitter effort, assigned to Scientific Committee 24 the task of examining tritiated thymidine to determine whether the values for pennissible body burdens and concentrations of tritium as tritiated water given in NCRP Report No. 22 would be applicable. As the Committee studied the problem, they decided it would be appropriate to examine all radionuclides and additional compounds that have the potential for incorporation into genetic material | NCRP REPORT No. 63 TRITIUM AND OTHER RADIONUCLIDE LABELED ORGANIC COMPOUNDS INCORPORATED IN GENETIC MATERIAL Recommendations of the NATIONAL COUNCIL ON RADIATION PROTECTION AND MEASUREMENTS Issued March 30 1979 National Council on Radiation Protection and Measurements 7910 WOODMONT AVENUE WASHINGTON . 20014 Copyright National Council on Radiation Protection and Measurements 1979 All rights reserved. This publication is protected by copyright. No part of this publication may be reproduced in any form or by any means including photocopying or utilized by any information storage and retrieval system without written permission from the copyright owner except for brief quotation in critical articles or reviews. Library of Congress Catalog Card Number 79-84486 International Standard Book Number 0-913392-47-2 Preface In 1968 the NCRP Board of Dừectors in an expansion of its internal emitter effort assigned to Scientific Committee 24 the task of examining tritiated thymidine to determine whether the values for permissible body burdens and concentrations of tritium as tritiated water given in NCRP Report No. 22 would be applicable. As the Committee studied the problem they decided it would be appropriate to examine all radionuclides and additional compounds that have the potential for incorporation into genetic material. The Committee has made a sincere effort to review the world s literature on the subject and to arrive at conclusions which would make it possible to derive appropriate standards for radiation protection in the use of labeled organic materials. After a brief introduction the report identifies those radionuclides of interest and the possible routes of exposure that may be encountered. There is a detailed review of the biological effects observed in man animals and plants. Approaches to calculations of dose and definition of a reference cell-nucleus are the subjects of the next section of the report. A separate section of the report is devoted to each of .