tailieunhanh - Báo cáo khoa học: Collective behavior in gene regulation: Post-transcriptional regulation and the temporal compartmentalization of cellular cycles

Self-sustained oscillations are perhaps the most studied objects in science. The accomplishment of such a task reliably and accurately requires the presence of specific control mechanisms to face the presence of variable and largely unpredictable environmental stimuli and noise. | ễFEBS Journal MINIREVIEW Collective behavior in gene regulation Post-transcriptional regulation and the temporal compartmentalization of cellular cycles Maria C. Palumbo1 Lorenzo Farina2 Alberto De Santis2 Alessandro Giuliani3 Alfredo Colosimo1 Giorgio Morelli4 and Ida Ruberti5 1 Department of Physiology and Pharmacology Sapienza University of Rome Italy 2 Department of Computer and Systems Science Antonio Ruberti Sapienza University of Rome Italy 3 Department of Environment and Primary Prevention Istituto Superiore di Sanita ISS Rome Italy 4 NationalResearch Institute for Food and Human Nutrition Rome Italy 5 NationalResearch Council Institute of Molecular Biology and Pathology Rome Italy Keywords metabolic cycle oscillations post-transcriptionalregulation RNA-binding proteins Correspondence L. Farina Dipartimento di Informatica e Sistemistica Antonio Ruberti Via Ariosto 25 00185 Rome Italy Fax 39 067 727 4088 Tel 39 064 457 526 E-mail Received 10 December 2007 revised 31 January 2008 accepted 26 February 2008 doi Self-sustained oscillations are perhaps the most studied objects in science. The accomplishment of such a task reliably and accurately requires the presence of specific control mechanisms to face the presence of variable and largely unpredictable environmental stimuli and noise. Self-sustained oscillations of transcript abundance are in fact widespread and are not limited to the reproductive cycle but are also observed during circadian rhythms metabolic cycles developmental cycles and so on. To date much of the literature has focused on the transcriptional machinery underlying control of the basic timing of transcript abundance. However mRNA abundance is known to be regulated at the post-transcriptional level also and the relative contribution of the two mechanisms to gene-expression programmes is currently a major challenge in molecular biology. Here we review recent results showing the .