tailieunhanh - Biomedical Engineering From Theory to Applications Part 17

Tham khảo tài liệu 'biomedical engineering from theory to applications part 17', kỹ thuật - công nghệ, cơ khí - chế tạo máy phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | 470 Biomedical Engineering - From Theory to Applications describe how strains and stresses are distributed within a cell Karcher et al. 2003 Vaziri et al. 2007 . The disadvantage of a continuum model lies in its ability to deal with discrete components such as cytoskeletons making it difficult to interpret the mechanical behaviours and interactions with discrete components and their contribution to the mechanical properties of a cell. In contrast to the continuum approaches discrete approaches treat the cytoskeleton as the main structural component and have been developed in particular to investigate the cytoskeletal mechanics in adherent cells Satcher and Dewey 1996 Stamenovic et al. 1996 . The microscopic spectrin-network model was developed for suspended cells such as erythrocytes to investigate the contribution of the cell membrane and spectrin network to the large deformation of red blood cells Boey et al. 1998 Li et al. 2005 . The tensegrity model consists of stress-supported struts which play the role of microtubules and cable-like structures which play the role of actin filaments Ingber 2003 . The tensegrity model depicts the cytoskeleton as a prestressed network of interconnected filaments investigating the effects on cellular shape and stiffness Stamenovic et al. 1996 . Because the tensegrity model is quite conceptual and does not consider other cellular components such as the cell membrane and cytoplasm difficulties arise when relating its findings to the physical relationships between the mechanical properties of a whole cell and its subcellular components. Basic concept of the mechano-cell model The mechanical properties of a cell are the result of the structural combination of subcellular components such as the cell membrane nuclear envelope and cytoskeleton. To understand the underlying process of how these subcellular components contribute to the cell as a whole it is essential to develop a cell model that displays continuum behaviour as a .