tailieunhanh - Chapter 104. Acute and Chronic Myeloid Leukemia (Part 5)

Morphology of AML cells. A. Uniform population of primitive myeloblasts with immature chromatin, nucleoli in some cells, and primary cytoplasmic granules. B. Leukemic myeloblast containing an Auer rod. C. Promyelocytic leukemia cells with prominent cytoplasmic primary granules. | Chapter 104. Acute and Chronic Myeloid Leukemia Part 5 Morphology of AML cells. A. Uniform population of primitive myeloblasts with immature chromatin nucleoli in some cells and primary cytoplasmic granules. B. Leukemic myeloblast containing an Auer rod. C. Promyelocytic leukemia cells with prominent cytoplasmic primary granules. D. Peroxidase stain shows dark blue color characteristic of peroxidase in granules in AML. Platelet counts 100 000 pL are found at diagnosis in 75 of patients and about 25 have counts 25 000 pL. Both morphologic and functional platelet abnormalities can be observed including large and bizarre shapes with abnormal granulation and inability of platelets to aggregate or adhere normally to one another. Pretreatment Evaluation Once the diagnosis of AML is suspected a rapid evaluation and initiation of appropriate therapy should follow Table 104-2 . In addition to clarifying the subtype of leukemia initial studies should evaluate the overall functional integrity of the major organ systems including the cardiovascular pulmonary hepatic and renal systems. Factors that have prognostic significance either for achieving complete remission CR or for predicting the duration of CR should also be assessed before initiating treatment. Leukemic cells should be obtained from all patients and cryopreserved for future use as new tests and therapeutics become available. All patients should be evaluated for infection. Table 104-2 Initial Diagnostic Evaluation and Management of Adult Patients with Acute Myeloid Leukemia History Increasing fatigue or decreased exercise tolerance anemia Excess bleeding or bleeding from unusual sites DIC thrombocytopenia Fevers or recurrent infections granulocytopenia Headache vision changes nonfocal neurologic abnormalities CNS leukemia or bleed Early satiety splenomegaly Family history of AML Fanconi Bloom or Kostmann syndromes or ataxia telangiectasia History of cancer exposure to alkylating agents radiation topoisomerase II .

• Y học thường thức
• Acute and Chronic Myeloid Leukemia
• bệnh học và điều trị
• bài giảng bệnh học
• tài liệu học ngành y
• Harrisons Internal Medicine
• Chronic myeloid leukemia
• Acute myeloid leukemia
• Imatinib mesylate
• Leukemia markers
• Anti leukemia drugs in myeloid leukemia
• BMC Cancer
• Acute lymphoblastic leukemia
• Chronic lymphocytic leukemia
• Case rep
• Chemotherapeutic agents
• Phase I
• Myelodysplastic syndrome
• Chronic myelomonocytic leukemia
• Acute lympho leukemia
• Hyperleukocytic symptoms
• Clinical symptoms of leukostatsis
• Pathology competencies
• Organ system pathology
• Myeloid neoplasia
• Myelodysplastic syndromes
• Myeloproliferative neoplasms
• Tobacco smoking
• Including chronic myeloid leukemia
• Tyrosine kinase inhibitor
• Hematopoietic stem cell transplantation
• Kinase inhibitors
• báo cáo khoa học
• báo cáo y học
• công trình nghiên cứu về y học
• tài liệu về y học
• cách trình bày báo cáo