tailieunhanh - Báo cáo khoa học: "Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors | J. Vet. Sci. 2009 10 1 1-7 DOI JOURNAL OF Veterinary Science Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors Chi-Ho Yu1 1 Du-Na Hwang1 1 Ji-Young Yhee1 Jong-Hyuk Kim1 Keum-Soon Im1 Whan-Gook Nho2 Young-Soo Lyoo1 Jung-Hyang Sur1 Department of Veterinary Pathobiology Small Animal Tumor Diagnostic Center College of Veterinary Medicine Konkuk University Seoul 143-701 Korea 2Department of Animal Science Korea National Agricultural College Hwaseong 445-760 Korea Primary testicular tumors are the most common causes of cancer in male dogs. Overall the majority of canine patients should be cured by testicular surgery. However tumor markers are not well-known in veterinary medicine. We sought to determine using immunohistochemistry whether the combined human testicular tumor markers placental alkaline phosphatase OCT3 4 CD30 alpha-fetoprotein inhibin-alpha vimentin c-KIT and desmin are expressed in canine seminomas and Sertoli cell tumors SCTs . We examined 35 canine testicular tumors 20 seminomas and 15 SCTs. c-KIT was expressed markedly in canine seminomas. Both inhibin-alpha and vimentin were expressed significantly in canine SCTs. The results of this study demonstrate differences and similarities between tumor marker expression of testicular tumors in dogs and humans. All the main markers in current routine use are discussed as well as potential useful markers for benign and malignant tumors and tumor progression. Keywords dog immunohistochemistry seminoma Sertoli cell tumor tumor markers Introduction Testicular tumors arise from germ cells and sex-cord stromal elements of the testis 22 and are divided into four general categories germ cell tumors including seminoma teratoma embryonal carcinoma and yolk sac carcinoma arising from the germinal epithelium of the seminiferous tubules sex-cord stromal tumors including Sertoli cell tumor SCT and Leydig interstitial cell tumor mixed germ cell sex-cord stromal