tailieunhanh - Chapter 107. Transfusion Biology and Therapy (Part 5)

Fresh-Frozen Plasma FFP contains stable coagulation factors and plasma proteins: fibrinogen, antithrombin, albumin, as well as proteins C and S. Indications for FFP include correction of coagulopathies, including the rapid reversal of warfarin; supplying deficient plasma proteins; and treatment of thrombotic thrombocytopenic purpura. FFP should not be routinely used to expand blood volume. FFP is an acellular component and does not transmit intracellular infections, ., CMV. Patients who are IgA-deficient and require plasma support should receive FFP from IgAdeficient donors to prevent anaphylaxis (see below). Cryoprecipitate Cryoprecipitate is a source of fibrinogen, factor VIII, and von Willebrand factor (vWF). . | Chapter 107. Transfusion Biology and Therapy Part 5 Fresh-Frozen Plasma FFP contains stable coagulation factors and plasma proteins fibrinogen antithrombin albumin as well as proteins C and S. Indications for FFP include correction of coagulopathies including the rapid reversal of warfarin supplying deficient plasma proteins and treatment of thrombotic thrombocytopenic purpura. FFP should not be routinely used to expand blood volume. FFP is an acellular component and does not transmit intracellular infections . CMV. Patients who are IgA-deficient and require plasma support should receive FFP from IgA-deficient donors to prevent anaphylaxis see below . Cryoprecipitate Cryoprecipitate is a source of fibrinogen factor VIII and von Willebrand factor vWF . It is ideal for supplying fibrinogen to the volume-sensitive patient. When factor VIII concentrates are not available cryoprecipitate may be used since each unit contains approximately 80 units of factor VIII. Cryoprecipitate may also supply vWF to patients with dysfunctional type II or absent type III von Willebrand disease. Plasma Derivatives Plasma from thousands of donors may be pooled to derive specific protein concentrates including albumin intravenous immunoglobulin antithrombin and coagulation factors. In addition donors who have high-titer antibodies to specific agents or antigens provide hyperimmune globulins such as anti-D RhoGam WinRho and antisera to hepatitis B virus HBV varicella-zoster virus CMV and other infectious agents. Adverse Reactions to Blood Transfusion Adverse reactions to transfused blood components occur despite multiple tests inspections and checks. Fortunately the most common reactions are not life-threatening although serious reactions can present with mild symptoms and signs. Some reactions can be reduced or prevented by modified filtered washed or irradiated blood components. When an adverse reaction is suspected the transfusion should be stopped and reported to the blood bank for .

• Y học thường thức
• Transfusion Biology and Therapy
• bệnh học và điều trị
• bài giảng bệnh học
• tài liệu học ngành y
• Harrisons Internal Medicine
• medical books
• pharmacology
• epidemiologic
• Obstetrics
• anatomy
• Preventing Morbidity
• Multidisciplinary Care