tailieunhanh - Báo cáo khoa học: "The effect of doxycycline on canine hip osteoarthritis: design of a 6- months clinical trial"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: The effect of doxycycline on canine hip osteoarthritis: design of a 6- months clinical trial | J. Vet. Sci. 2009 10 3 239-247 DOI JOURNAL OF Veterinary Science The effect of doxycycline on canine hip osteoarthritis design of a 6months clinical trial Korakot Nganvongpanit1 3 Peraphan Pothacharoen3 Niyada Suwankong1 2 Siriwan Ong-Chai1 3 Prachya Kongtawelert1 3 Bone and Joint Research Laboratory Department of Veterinary Biosciences and Public Health and 2Department of Small Animal Clinic Faculty of Veterinary Medicine Chiang Mai University Chiang Mai 50100 Thailand 3Thailand Excellence Center for Tissue Engineering Department of Biochemistry Faculty of Medicine Chiang Mai University Chiang Mai 50000 Thailand Twenty-five dogs were included in a randomized doubleblind trial to assess the efficacy of doxycycline DOX orally administered twice a day at 4 mg kg day n 12 for the treatment of osteoarthritis of the hip. Chondroitin sulfate CS 525 mg day was used as a positive control n 13 . Dogs were re-examined monthly for 6 months after initiation of treatment. The assessment protocol included clinical score radiographic findings and serum osteoarthritis biomarkers. Dogs treated with DOX showed statistically significant improvements p in lameness joint mobility pain on palpation weight-bearing and overall score at 2 6 4 4 and 4 months respectively after treatment. Biomarker levels of CS-WF6 epitope and hyaluronan were significantly increased and decreased p at 2 and 3 months after treatment compared to pretreatment. These results showed that DOX had a positive therapeutic effect in dogs with osteoarthritis. Keywords biomarkers canine chondroitin sulfate doxycycline osteoarthritis Introduction Osteoarthritis OA is a chronic disabling condition for which there are no cure and few useful treatments 9 . Clinical features include joint pain instability limitation of motion and function impairment. The pathogenesis of OA albeit not yet well understood is often linked to joint injury biochemical alterations and ageing 20 . Pharmacological

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