tailieunhanh - Neurological Differential Diagnosis - part 6

Viêm khớp dạng thấp ◆ chung rối loạn ảnh hưởng đến 2-5% dân số nói chung. ◆ neuropathies ngoại vi xảy ra trong 10% bệnh nhân. ◆ Neuropathies có thể được nén trung ammation infl và xơ hóa, hoặc đối xứng, cảm giác, viêm đa thần kinh | 266 Chapter 7 2 Rheumatoid arthritis Common disorder affecting 2-5 of the general population. Peripheral neuropathies occur in up 10 of patients. Neuropathies can be compressive secondary to inflammation and fibrosis or symmetric sensory distal polyneuropathy mononeuropathy mononeuropa-thy multiplex and fulminant sensorimotor polyneuropathy due to vasculitis or vascular occlusion. 3 Vasculitis Spectrum of disorders characterized by inflammation of blood vessels and resultant luminal occlusion with downstream tissue ischemia. Peripheral nerve involvement is common. Broadly characterized as systemic necrotizing vasculitis hypersensitivity vasculitis giant cell arteritis or localized vasculitis. 4 Sarcoidosis Multisystem granulomatous disorder. 5 of patients have neurological manifestations. Cranial neuropathies are the most common neurological manifestation 73 . Additional neurological manifestations include multiple motor sensory mononeuropathies polyradiculoneuropathies cauda equina syndrome and symmetric sensorimotor neuropathy. 5 Amyloidosis Multisystem disorder characterized by extracellular deposition of P-pleated sheet fibrillar proteins. Usually presents after age 40 men affected 2 1 over women. Peripheral neuropathy present in 10-35 of patients. Clinical symptoms include painful dysesthesias with decrement in spinothalamic modalities carpal tunnel syndrome and dysautonomia. 6 Systemic sclerosis Connective tissue disease characterized by excessive collagen deposition. Neurological complications include myopathies but are uncommon. Inflammatory demyelinating polyradiculopathies Acquired immune-mediated demyelinating diseases characterized primarily by their clinical course as chronic or acute. Acute forms with maximal deficits occurring within 4 weeks of illness are classified as Guillain-Barré syndromes. Disease with chronic progression or multiple relapses is classified as chronic inflammatory demyelinating polyradiculopathy CIDP . Infectious Inflammatory .